ABSTRACT
Gastro duodenal ulcer is a common disorder of the gastrointestinal tract. Several Indian medicinal plants have been traditionally and extensively used to prevent different diseases. In the present research studies, Bael fruit [Aegle marmelos [AM], family: Rutaceae] which are also called as Bilva in ancient Sanskrit was used as a herbal drug and its antioxidative role in aspirin- induced gastroduodenal ulceration in albino rat was evaluated using essential biochemical parameters. Mucosal thickness [MT], ulcer index [UI], different biochemical parameters, such as aspartate aminotransferase [AST], alanine aminotransferase [ALT], catalase [CAT], superoxide dismutase [SOD], reduced glutathione [GSH], and lipid peroxidation [LPO] were measured in all the groups, to study the possible involvement of antioxidants with gastroduodenal protection. A significant decrease in MT, SOD and CAT activities and GSH level and a significant increase in UI, AST, ALT, and ALP activities and LPO level were observed in aspirin treated stomach and duodenum of albino rats. Pretreatment with AM fruit pulp extract for 14 consecutive days showed the reverse effects of aspirin suggesting gastro-duodenal protective and anti- ulcerogenic properties of AM through its antioxidant mechanism
Subject(s)
Animals, Laboratory , Peptic Ulcer/therapy , Aspirin/adverse effects , Anti-Ulcer Agents , Anti-Inflammatory Agents, Non-Steroidal , Antioxidants , RatsABSTRACT
Two rare cases of adenocarcinoma of the caecum and ascending colon concomitant with tuberculosis at the same site are reported. The plausibility of an aetiological relationship between the two pathological conditions has been discussed along with a review of the relevant literature. Tuberculosis complicating malignant disease is a diagnostic and therapeutic challenge; and the likelihood of the two occurring together should be kept in mind especially in tuberculosis endemic areas and in patients with equivocal symptoms